There is no single answer to this. The most important is to find a schedule that works best for you. Two famous microdosing schedules are described by James Fadiman – single microdose days separated by off days and Paul Stamets – serial microdose days separated by off days. 

Fadiman:  Day 1: dose day – Day 2: no dose – Day 3: no dose – Day 4: dose day.

Stamets:  4 serial dose days – 3 days no dose.

Off days are important to observe the difference and not to build a tolerance. When continuing your schedule for several weeks it is recommended to take a break for some weeks. Again to observe the effects, see what the short-term, in-the-moment and long-term effects are. Take notes! Be kind to yourself and regularly check in with your purpose and intention. You don’t have to follow a schedule like this and can also microdose more randomly when you like and feel to, it all depends on your goals. If you want to know more about microdosing protocols you can check out this info from the Microdosing Institute.